Very Quick Computer Specs:
3.06 ghz Intel Core 2 duo
4 gb ram
Nvidia GeForce 9400 (with 256mb vram)
First off, don't even pretend that you'll be able to play on Medium Grpahics settings. Put everything on low, and work your way up from there.
General Computer Tweaks
These tips are applicable to all games, not just Skyrim, and they're all useful.
10 Tips How To Make Skyrim Run Faster
Additionally, lowering the pre-render frames (For those with Nvidia graphics cards) will noticeably decrease lag. To do so, head over to your control panel, and under the graphics card #d Settings, find Maximum pre-rendered Frames (The default is 3), and change it to 1. If you don't want it as a universal setting (I sure didn't), they just set it to be used when running TESV.exe
For some strange reason, shadows cannot be disabled in skyrim, and on low quality settings, they look awful. As such, disabling them is probably the best choice of action for a large performance boost. Head over to your SkyrimPrefs.ini and under [Display], set fInteriorShadowDistance and fShadowDistance to 0.
Increasing Allocated Memory
By default, Skyrim will only use a certain amount of your computer's memory. By adding this to your Skyrim prefs, you can increase the allocated memory to the maximum possible (if you have 4 gigs of ram and are using a 64bit OS), which prevents lag when you walk out into a crowd of people, in battles, etc. It won't increase FPS, but decreases frequency and intensity of FPS drops for smoother gameplay.
Disable Mouse accleration and vSync
Add the followingline to the bottom of [Display] to disable Vsync: iPresentInterval=0
Additionally, under [Controls], find bmouseAcceleration=1, and change it to 0.
Skyrim Better Performance upps FPS noticeably without any reduction in Graphics Quality. Great regardless of your settings
TESV Reduced Texture Pack also increases FPS, though there is a slight reduction in Graphics Quality. However, this was the last bit I needed to get the game to a playable state.
More details to come as they're released/discovered/whatever.
PS: If you all have ideas that aren't posted here, feel free to do so, and I'll add them.
Edited by Wallam, 14 November 2011 - 11:49 PM.