I managed to get Wyre Bash 307 beta 2 to work by disabling Autosort in Vortex. This is with the original Skyrim, btw. 306 seems to work with Autosort enabled, but suffers from weird sorting issues, e.g. using Loot sorts the load order, then when you open Wyre Bash the load order changes, with things like Update.esm being placed after the DLCs.