Hi everyone!
I played Skyrim for years with several mods and understood something about the game's and mods' mechanisms as well, and I generally resolved mod-related bugs by myself.
Recently, anyway, I had a persistent trouble with the interaction (key "E" on PC). I think it can be related with Animations by Genebriss (http://www.nexusmods.com/skyrim/mods/51554/), because issues started to appear quite after I installed it. My problem is that, sometimes, a follower (dogs too) stops to interact with me, i.e. when I type "E" on it, it doesn't open the talk window - FOREVER. No console commands such ase 'ResetAI' worked in any combination. It doesn't seem to be a specific trigger, since the issue doesn't reappear if I load an old save (for old, I mean before the issue appearance); anyway, it can affect a different follower in a different time.
Similar bugs appeared on corpses (couldn't loot), and today on my room door in Candlehearth Hall (since I use RND, I need to sleep). No 'pcb' or similar commands helped. Deactivating "Animations" didn't unlocked the door too.
Now, I have a backup save before the issues apperaed, but it's 2-3 quests before my actual progress. I have a very lore-friendly gameplay, so I can take days to end a quest (also, because I don't have too much time to play, right now), so I'd prefer to continue my game from where I'm now, if possible, with this bug resolved - or, if I need to load that very old save, to be sure that I will no more have this type of bug.
I'm not a noob, so I'm not asking you "help, you must do something to me", but I would try to understand the possible underlying mechanism of a this interaction/activator bug.
Here are all my active mods:
00 Skyrim.esm
01 Update.esm
02 Unofficial Skyrim Patch.esp [Version 2.0.0a]
03 Dawnguard.esm
04 Unofficial Dawnguard Patch.esp [Version 2.0.0b]
05 HearthFires.esm
06 Unofficial Hearthfire Patch.esp [Version 2.0.0]
07 Dragonborn.esm
08 Unofficial Dragonborn Patch.esp [Version 2.0.0]
09 Skyrim Project Optimization - Full Version.esm
0A ClimatesOfTamriel.esm
0B JSwords.esm
0C Solstheim Climate Overhaul.esm
0D SMPC.esp
0E TKChildren.esm
0F MoreFixes.esp [Version 1.35]
10 temp_DG_missing_dialogue.esp
11 Chesko_Frostfall.esp
12 FrostfallAllWinter.esp
13 Sosltheim Climate Overhaul - Extreme Wasteland Patch.esp
14 ClimatesOfTamriel-Sound.esp
15 StaticMeshImprovementMod.esp
16 StaticMeshImprovementMod-DragonbornTernFix.esp
17 StaticMeshImprovementMod-FurnitureChestSnowFix.esp
18 Dead Body Collision.esp
19 earlier health warnings.esp
1A Grimsever_USKP_unfix.esp [Version erts]
1B Libri ITA fix.esp
1C Necromage Fix.esp
1D WetandCold.esp
1E WetandCold - Ashes.esp
1F Character Creation Overhaul.esp
20 RaceMenu.esp
21 RaceMenuPlugin.esp
22 RaceMenuOverlays.esp
23 SkyUI.esp
24 Cloaks.esp
25 Cloaks - Dawnguard.esp
26 1nivWICCloaks.esp [Version 2.3]
27 1nivWICSkyCloaksPatch.esp [Version 2.3]
28 DK_Armor_By_Hothtrooper44.esp
29 Northborn FurHoods.esp
2A 1nivWICSkyCloasNorthPatch.esp [Version 2.3]
2B PlatedMagiArmoresp
2C SamuraiArmor.esp
2D VagabondArmor.esp
2E VanguardArmor.esp
2F VikingArmor.esp
30 warchiefarmor.esp
31 Dr_Bandolier.esp
32 ERSO 03 - Mighty Dragons Unleveled DG.esp
33 ERSO 03.3 - Mighty Dawnguard Dragons.esp
34 ERSO 03.4 - Mighty Dragonborn Dragons.esp
35 ERSO 03.5 - New Dragon Super Loots.esp
36 ERSO 04 - Mighty Odahviing.esp
37 ERSO 04.2 - Mighty Durnehviir.esp
38 ERSO 05 - Dovah Holy Book.esp
++ ERSO 06 - Wait More Time Dragon Encounter x3.0.esp
39 ERSO 07 - Mighty Dragon Priests.esp
3A ERSO 09 - Vendor Trainer Quest-giver protected USKP.esp
3B SkyRe_Main.esp
3C SkyRe_Combat.esp
3D SkyRe_EncounterZones.esp
3E SkyRe_EnemyAI.esp
3F SkyRe_EnemyScaling.esp
40 SkyRe_StandingStones.esp
41 SkyRe_Survivalism.esp
42 SkyRe_Plugin_JaySuSSwords_1.3D.esp
43 Unique Uniques.esp [Version 1.5]
44 Alastherium.esp
45 Convenient Horse Herding.esp
46 Fort Ironcrag.esp
47 The Paarthurnax Dilemma.esp [Version 1.2.5]
48 360WalkandRunPlus-RunBackwardSpeedAdjust.esp
49 CCO - Oblivion Carry Weights.esp
4A CCO - Permanent Birthsigns.esp
4B SkyTEST-RealisticAnimals&Predators.esp
4C SkyTEST-RealisticAnimals&Predators-Dawnguard.esp
4D SkyTEST-RealisticAnimals&Predators-Dragonborn.esp
4E Convenient Horses.esp
4F dD - Enhanced Blood Main.esp
50 dD-Dragonborn-Dawnguard-EBT Patch.esp
51 TheChoiceIsYours.esp
52 TheChoiceIsYours_Dawnguard.esp
53 TimingIsEverything.esp
54 aMidianborn_Skyforge_Weapons.esp
55 ImpeREAL Empire - Unique Cities - Falkreath.esp
56 Storefront.esp [Version 1.0.1]
57 Realistic Lighting Overhaul - Dungeons.esp
58 Realistic Lighting Overhaul - Dawnguard Interiors.esp
59 Realistic Lighting Overhaul - Major City Exteriors.esp
5A Realistic Lighting Overhaul - Major City Interiors.esp
5B Realistic Lighting Overhaul - Minor Cities and Town Interiors.esp
5C ClimatesOfTamriel-Dawnguard-Patch.esp
5D ClimatesOfTamriel-Dragonborn-Patch.esp
5E Solstheim Climate Overhaul - COT compatibility.esp
5F ClimatesOfTamriel-WinterEdition.esp
60 Supreme Storms - Cot Version.esp
61 CoT-WeatherPatch.esp
62 CoT-WeatherPatch_DB.esp
63 CoT-WeatherPatch_SupStorms.esp
64 CoT-WeatherPatch_NL4.esp
65 RealisticNeedsandDiseases.esp
66 RND_Dawnguard-Patch.esp
67 RND_HearthFires-Patch.esp
68 RND_Dragonborn-Patch.esp
69 RND_USKP-Patch.esp
6A Apocalypse - The Spell Package.esp
6B dovahkiinrelax.esp
6C ShowRaceMenuAlternative.esp
6D CCO - Dynamic Skill Progression.esp
6E No Skill Limit.esp
6F MorePP.esp
70 dD-No Spinning Death Animation.esp
71 Beards.esp
72 Improved Eyes Skyrim.esp
73 Improved Eyes Skyrim - Vamp.esp
74 CCO - Diverse Races And Genders.esp
75 SkyRe_Races.esp
76 WATER.esp
77 WATER DG.esp
78 WATER DB Waves.esp
79 GreenWaterFix_v2withDawnguard.esp
7A WaterFromWellsDragonbornRND.esp
7B ReProccer.esp
7C temp_coffins.esp
7D DF127RiversideShack.esp
7E TKChildren_HF.esp
7F TKChildren_V.esp
80 TKChildren_DB.esp
81 childskeletonfix.esp
82 RND_AnimalLoot.esp
83 SkyFalls + SkyMills + DG + DB.esp
84 SkyFalls Dragonborn Small waterfalls.esp
85 Realistic Fast Travel.esp
86 WarmongerArmory_Vanilla.esp
87 WarmongerArmory_DLC.esp
88 Torcs_35.esp
89 MoonGlow.esp
8A CommonClothes.esp [Version 92]
8B Animations.esp
8C AHZmoreHUD.esp [Version 1.0.0]
8D KJ Tattoos.esp
8E LC_BecomeJarlofIvarstead.esp
8F DnnUniqueBorderGates.esp
90 UFO - Ultimate Follower Overhaul.esp
91 UFO - Dawnguard AddOn.esp
92 UFO - Heartfire AddOn.esp
93 Bashed Patch, 0.esp