I have this weird issue with Skyrim on Windows 8 Pro x64.
Every time TESV.exe uses about 2GB of RAM the game crashes to desktop or freezes completely. I am using the latest version of Skyrim. Also I checked if the large address space awareness (LAA) flag was set on the TESV.exe, wich is set. When I was using Windows 7 x64 I have not had this problem. Does anyone else have this problem, and if yes do you know a way to fix it?