I recently updated to Windows 10 preview build 9879 from build 9860 in the hope that it would solve a crashing problem.
To my disappointment it continued to crash on start-up when trying to load Skyrim.
Recently I saw that they ported to Net Framework 4.5 and I tried the NMM build 0.50.1 and it works perfectly.
So I think its got something to do with either my incomplete OS or the NMM thing itself.
As I type I'm downloading heaps of installers for Net Framework 4.5 and its components so hopefully that will do the trick.
Anyway, if you have a way to solve this let me know.