I was able to get the game started by choosing a new game, but it CTD when I entered Helgen Keep. Really bummed, no clue what's causing this.
I would suggest checking your load order, for ENB related crashes occur when starting the game, not while playing it.
Other than that, I would suggest that you check the same things that I have described below.
I'm not sure if this is related, but I've started having an issue where certain mods that have never caused me a problem are suddenly all causing the exact same problem. When I start skyrim, the "Bathesda" logo does not show up, even though the sound still plays. When I load a save, the load screen doesn't show anything aside from my level and the fog down at the bottom of the screen. Then when I try to do anything that involves another load screen (in this case leaving Whiterun Castle, both by going out the door and Fast Traveling) I get a totally black screen and my game completely freezes. I managed to find all the mods causing the issue, but all are ones I REALLY want. Anyone know what's going on?
Did you change your load order after installing Windows 10? Did you clean install or just upgrade? If you just upgraded, make sure to get the Windows 10 drivers for chipset, LAN, GPU and audio devices. I don't see really that old versions for some of those would cause problems with the game, but they sure are not optimal for your computer. If you cannot find/don't feel confident installing drivers, get at least the GPU driver. If the problem persists (and you haven't clean installed) you could try to clean install your Windows 10. Make sure to back up your important files before this!
Hope this helps
Edited by williamlee, 10 August 2015 - 05:02 AM.