Similar to the Skyrim mod/setting that let arrows hit from across the continent (which was very awesome for testing your bow skills), It would be nice to see this for the guns in Fallout. The Range stat on the weapon doesn't seem to matter here. I tested a 150 and 300+ range laser gun, which both stopped hitting the target at the same fixed distance.
I use pistols and just made my first long recon scope on a laser pistol. I headed towards the vault from Sanctuary and tested it by shooting a stationary companion in Sanctuary, and once I got a bit up the hill, none of my guns would hit anymore. I know this isn't a huge deal in this game but it would be nice to have a fix. If I can see an enemy, I want to be able to hit them.
This was the "skyrim.ini" fix, but that didn't seem to work, but I have noticed that projectile weapons like my Plasma Pistol went much farther than hit-scan guns like the laser pistol. So I guess for now I'll have to put a big scope on a plasma weapon.