Well, I have to chime in here..
I have been playing FO4 for many, many real-days now ... all of it in the surrounding areas of the 'inner city' of Boston.
There has not been ONE crash ... no glitches, no freezes, no CTD's, NOTHING, Nada!!
Then I started into the city and BOOM! crash! CTD!! ... i tried and tried .... there is a 'line of death' drawn around Boston. It is real and consistant.
This is totally STUPID!
I love FO4 .... I HATE BETHESDA STUDIOS!
You would think they would care enough to help on this issue.