The site is functional in Explorer but not so with firefox this is the only thing I would like to see changed as all sites should be optimized for both anyway. As far as aesthetics the only thing that needs a bit of work is the banner image it is fine but something that is a good representation of the amazing graphics or the increadibely talented mods that are on this site a reflection of the community may need some work. If you want you could always make customized style sheets available to donators of the site to make it a worthwhile way to spend your time...Just an idea.
Tessa.
I use FireFox & it works great. Do you want some kind of collage for the banner?
I think this one is good

I personally prefer menus on the left (ala Planet Elder Scrolls, however that has it on both sides). But the thing i find really annoying about nexus is the bloody ads in the middle of the description of mods and comments! It really takes away from the site. Once again, a reference to PES, it has ads only on the top and a little bit of the right side! So, obviously my first choice is PES, not only because of these reasons but because new mods are displayed on the right side. Nexus doesn't have anyway to find new mods apart from a manual search. Man, I think you really stuffed up this site.
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Papa Smurf was here.
TES Nexus is a lot better than PES & the reality of it is that the ads pay the bills and Dark0ne should put them wherever he thinks they should be period.
There are plenty of ways to find new mods as Dark0ne points out (not just Manually searching), this site ROCKS.