Many times it is better to have a separate mods folder for those you must install manually, I put a folder labeled "ImportedMods" in my 'mods' folder, then place all the .7z's in that folder... open up NMM and use the green plus symbol and select 'Add Mod From File' then select the .7z I wish to install. NMM should install your files appropriately, however this will not work with your compatibility patches as they contain SEVERAL different .esp's. It can be a bit complex... if a .7z does not have a relevant directory path inside of it, then NMM will probably not know what to do with the files. Or decompress them in undesirable places.
Interesting NPC's, is a BIG one, however it should work with the above described method.
And as the previous poster said ENBoost must be manually placed in the ...Skyrim\ directory. Personally I use the 'Wrapper' version as it is designed to do just that... WRAP the files around your install of Skyrim. At least that's what I gathered from what I read about it.
As long as you READ and follow directions through the processes that most mods provide you should begin to understand how all this works.