Long time FO4 player. Started suffering CTD after playing around with Sim Settlements and not getting it to work. Eventually, I uninstalled all mods and game. Reinstalled FO4. CTD after starting new game. After an entire day of troubleshooting, pinpointed the problem to adding
Remove this, game loads fine with either vanilla or F4SE. Add that, CTD when trying to load save on brand new game. Found several forums on this but no solution. I do not have an interface folder. Game is completely fresh.