With Requiem can I generally use New Land/Quest Mods

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What I mean is. Is there any big problems (game-breaking) or smaller inconvinient troubles if I use

such mods with Requiem.

 

In my knowledge (might be wrong), some mods need to be made to work with Requiem. Example if add new

items/npc:S to game they need to adjust to Requiem standards)

 

Or is there just some armor's or weapons not balanced to Requiem world, same with the enemies.