We will get you going. But you will need a little patience.
I recommend anyone read the entire "FNV General Mod Use Advice" article to understand the differences between this game and others you may have experience with; especially if this is your first attempt to play a modded FNV or it's been more than a year since you last did so. It is designed for someone who has never played a modded PC game before, so it tries to avoid making any assumptions, is kept "up-to-date", and covers years of "lessons learned".
Something JUST released and not yet covered in that article you should look at is this post. But wait until you have a stable basic game before you install it, just to be safe. It is so new there may be extreme cases not yet discovered and shouldn't make a difference to someone just getting started.
If you still need help, please provide ALL the information requested in the wiki "How to ask for help" article. Don't forget to identify things that do not appear in the "load order", such as the version of Windows, if you are using a "Steam" or "GOG" and/or "regional language version" of the game (even if you are playing it in English); using the FNV4GB Patch, NVSE and it's related plugins; replacements for textures (specifically their larger image sizes: 1024x1024, etc.), animations, or "bodies", etc.; and "post-processors" like ENB or SweetFX. It saves us playing "20 questions" and gets you a more specific answer more quickly. (The usual turn-around on post and reply in an older game forum is 24 hours.) Screenshots of the "load order" don't usually work so well because they tend to cut off or fail to display needed information and are hard to "piece together" into a complete and coherent picture.
* See "How to markup images (etc) in forum posts and comments" article for how to use "Spoiler tags". "LOOT" already includes those tags in the "load order" it copies to your clipboard, so you can just paste it's list into your post.
Please see the 'Vanilla Load Order' entry in the 'First Timer Advice' section; and the 'Common Game Problems' section of the wiki "FNV General Mod Use Advice" article.
If the problem persists, then see either the 'Solutions to Starting the game problems' or the 'Solutions to "Crash To Desktop" (CTD) problems' sections in the wiki "Fallout NV Mod Conflict Troubleshooting" guide.
Edited by dubiousintent, 21 April 2020 - 12:44 PM.