Vortex is very easy to use, and Nexus of course supports it naively. MO2 seems very popular among LE > SE transfers, probably like many things, because of a certain amount of "Brand loyalty" and/or previous experience with mod managers.
For me, Vortex is largely effortless to use and was ~easy to learn, with the possible exception of its handling of load order issues, which, although largely an almost mindless process - it normally advises you to load before(suggested), load after(suggested) with a high degree of accuracy when a load contention needs to be resolved - well... imo could be done with a bit less mystery in the exceptional case when more complex load order decisions need to be made, with just a bit more effort by its developers in the UI included instructions (more words, more clarity, and maybe even some graphics like flow charts).
Even with that last bit said, I've had very few problems in installing ~500 hundred mods or so, and most problems I've had have been faulty mods, irreconcilable mod incompatibilities, and my own mistakes - like installing LE mods when I first began playing and didn't realize they are different and most often incompatible mods for SE, ie, Skyrim(LE, oldrim) vs Skyrim SE.
Installing and uninstalling mods is easy with Vortex. from nexus there's a download link for most mods that automatically links to Vortex (that is,m clicking the vortex button for a give mod with automatically download the mod and install it, prompting you only to answer certain questions presented by the mod installation configuration prompts (unique and not always part of a mod install) or when a load contention needs to be resolved. And if one prefers to manually download a file then install locally (from Nexus or elsewhere), that's supported as well (although direct vortex downloads have a few positives like notifying you when updates are available, author info, and so forth)
I don't care which you choose. I hope you choose the one best suited to you. But if all your buds use a specific mod manager, I'd suggest that you use it too... for the peace of the King! Just sharing the only perspective I can offer, since I've never used MO2. I'm sure its users can and will chime in with their own positives for MO2.