I have no clue if it's even possible... perhaps to be able to affect one 'type' of NPC? Perhaps like ...flag the guards to have a specific run.
I say this, because my wife gave me a hypothetical question that if she "could find a Naruto run animation, how badly would I kick her ass if she installed it while I wasn't aware of it." (we share the same PC sometimes.)
And that actually got me to laugh, because... could you imagine? The Curier or the Guards ONLY Naruto running everywhere. It'd be the funniest s***.
While the idea is hilarious but it could be very useful for other animations... for example, ghosts could float around instead of walking, or wenches could just sexy walk everywhere.
Now the other things are; tophat mudcrabs and the mudcrabs that go "I Peench". I haven't seen that yet ported over and I dearly miss my dapper tasty fellows.
https://www.nexusmod...kyrim/mods/5932 - Posh Mudcrabs (I'm aware of the comments explaining how, but I just have no clue how to run any of that.)
https://www.nexusmod...yrim/mods/36715 - The I Pinch mudcrab sounds. These two together were the only non-lore friendly mods I ever had with Skyrim and I still wish I could have them again.