Was that addressed to the OP, or me?
Have also been merging, trying out zEdit which is a new streamlined xEdit, still leaning on FO4edit though.
Otherwise, agree with all your above, have been on a quite similar path with much different content, can't imagine what you game looks like with all those mods.
Am up to 367 installed reduced to 271 actual plugins and 247 "active" ones by munging them together and getting wise in general.
Don't rightly know how many are esls, I don't even convert them anymore, just suck em up into other (related) mods as needed.
(I try to save a few slots before 255 for testing/creating/merging and later when comfortably tested/debugged for quests|iDLCs like OaR).
4:5 of anything left out has a script attached to it, everything else is being scrutinized/sanitized.
Looking to make a few fat ESPs and mega merged BA2s for a finale.
Freaking myself out last few days how silky smooth it's gotten in some previously rough spots in the worldspace, even with SS:Conqueror Downtown Boston, Financial District.
Not without its glitches, but almost entirely bug free now.
After five years from release, and a year of me getting up to speed, this horse might finally win, place or show among my favorite game(s) ever.
Said it elsewhere:
"This is Fallout 4 it's educational, not recreational."
But learning is so much fun!