Using OP's example, isn't the answer to his question simply this - the last Fallout 4 profile enabled before switching to Skyrim? Or am I totally misunderstanding the issue?
Yes, but if he has four Fallout 4 profiles, and he uses Fallout 4 profile #2, and then switches to Subnautica, and then decides to play Fallout 34 some more a couple of months later, what is there in Vortex that will let him know that Fallout 4 Profile 2 is the one he last played, without having to switch Vortex back to Fallout 4 to find out?
It'd be nice if the profile had a little flag or something, like the "Set Primary" thing does.
That way, he can just look at RECENTLY MANAGED, and see the profile with the flag and know, "Oh ok, it's profile two that I last played" without having to switch Vortex over to Fallout 4.
Look at this screenshot and tell me which Subnautica Profile is the last one I played
Why do you have two Subnauticas?