I am unable to get any antialiasing, anisotropic filtering, etc. set up through the Nvidia control panel to work when I run Skyrim through Mod Organizer (using SKSE) and the Real Like ENB. Even at 1920 x 1080, the jaggies are still pretty nasty.
However, Nvidia Control Panel settings work fine when running the game through the standard launcher. I am using the most up-to-date versions of all software mentioned (with the exception of the 1.9 beta patch).
Any ideas why this would be happening?