Very recently (it was not a problem a week or so ago using 2.0.6) I'm having the same problem with the quest that several others mentioned; Jonestead, and Euphorbia Palace disappearing. With some of the earlier versions of SMSkyrim 2 there weren't any apparent problems. With versions 2.2, 2.1.1, and and perhaps 2.1 Jonestead and Euphorbia Palace disappeared from the map. I ran "cow SMSJonestead 0 0" and Jonestead is not recognized. I loaded an old save game inside Jonestead from episode 1 and Jonestead was still not recognized with SMSkyrim.esp versions 2.1.1 or 2.2. Previously the Sexy Maid of Skyrim quest from episode 1 showed up in the completed quest list, but it has now vanished. I am running Skyrim (Tesv.exe) version 1.7 since the silent voice mod (and some other mods by the same author) won't be available for Skyrim 1.8 for a while. I don't have Dawnguard or Hearthfire. I use Wrye Bash 301 to manage mods. I made sure that SMSkyrim.esp was loaded and active; I even moved it to the end of the load list. I'm using the loose files (non BSA) version of SMSkyrim. I loaded SMSkyrim into TES5Edit by itself (with skyrim.esm/update.esm of course) as well as with all of the other mods active and I didn't see anything obviously wrong (I didn't see any mods changing the SMSkyrim entries I looked at), but I'm not sure exactly what to look for with this issue. I'll continue looking at other mods I have loaded to make sure they didn't cause this.
