you can take the practical yet boring approach. I focus on Guns as my primary attack, melee weapons as my secondary attack, Repair to make caps, Medicine to live, and sneak to get in those critical hits (you need a suppressed weapon to use sneak properly, my recommendation the sniper rifle and learn to snipe from a great distance. FYI if you hit a surface the enemies will investigate where the bullet hit, great for getting them out of cover.) Boone is an all around and very dangerous companion, he decapitates enemies very easily with his rifle. Guns skill is one of the most practical skills. Conventional firearms are prevalent, efficient and in the end cheap.