Just adding my voice to the growing list of people experiencing this bug. It's driving me nuts. I can get through about 15-20 minutes of gameplay before experiencing the bug. Sometimes I keep playing without noticing it until I start getting message boxes with no dialogue or my Hearthfire children and other certain NPCs don't speak, then I have to reload. I don't even know where to begin to look because I have over 200 mods. I made sure they are sorted properly and all saved in form 44. I merged some plugins and created a Bashed Patch. My game runs smoothly and I never get any crashes. It's only this dumb bug that is keeping me from enjoying the game. I feel like I started noticing the problem more frequently when I started using SSE Fixes, but it was long enough ago that I can't remember if I added any other mods at the time, so I can't say with certainty that there is a direct connection. Also I don't use OBIS Loot but I do use Frostfall , iNeed, and Wet and Cold, as well as Convenient Horses, a lot of Enai Siaion's mods, RDO, Better Vampires, and a lot of Hearthfire mods like Multi Adopt and Improved Adoptions. I also use SkyUI and I have subtitles enabled.