I occasionally CTD'd even though the game was working fine 10 seconds earlier. I open up the Config Tool and change nothing, just save, and then my game suddenly works again. This stopped for me after I changed Virtual Install folders. Some of you say mod files aren't loading from the Data folder and cause a CTD except assumingly exe/esm/esp filetypes. Do you have NMM installed on a different harddrive then the where the games installation is? If so keep reading otherwise the following probably won't help you. NMM has been updated recently to install your mods into the VirtualMods folder within the mod managers installation. For me this was D:\Games\Nexus Mod Manager\Fallout4\Mods\Virtualinstall. Then it places symbolic links to the mod file locations inside your Fallout 4 data folder, which I had moved to my SSD located at C:\Games\Fallout 4. If the game and mods are on different drives it will not be able to load them, you'll get blank 0kb files IE: Missing meshes, textures, sounds etc. Open NMM and select tools, change virtual folders and enable multi-hd install mode. Alternatively use the tool to move the Virtual Install folder path to be on the same harddrive as your fallout 4 installation. (WARNING: This reinstalls all your mods so if you personalised any .esp files after NMM installed them: BACK THEM UP!) That's what I did since I wanted my mods to load from an SSD not a HDD. Certain files such as .exe, .esm and .esp cannot be symlinked and need to physically be located within the data folder that's why you've been able to load those.