Hm, a few things here: 1. Don't use NMM for oblivion, use wrye bash. 2. How large are your current save games? 3. Do NOT overwrite your save games, make completely new ones, and never use quicksave, overwriting the same file might, and with many mods WILL cause corruption eventually. 4. Do not reload from ingame, due to the engine, it will not rerun certain scripts as intended and will also cause corruption over a long period of time, or leave certain mods barely functional. So basically, if you want to reload, quit the game, start it up again. 5. Out of curiousity, what's your current load order?