Please don't forget that a door is actually a mechanism to connect one interior/exterior "cell" to another, in the game. In case of chests, it is a separate container object like your inventory. In fact, every shopkeeper in Skyrim has a hidden chest/box that forms their shop inventory! This means that even if you have a nuke-level destruction spell, it will not transport you beyond the door or open that chest's container. So, we cannot amp-up existing destruction spells, we would need completely new spells to unlock doors/chests, similar to what wirkoenntenaber has suggested. NORMAL SOLUTIONS: If you are roleplaying as a thief, and want to have an easier way to pick locks, then I suggest you visit the Tower Stone. The Tower Stone's ability allows you to unlock any Expert (or lower-level) lock, instead of picking it. (Perhaps someone can create a mod, to convert this inbuilt ability into a permanent toggleable spell/power, like the Khajiit Night-Eye?) You might also want to visit the Thief Stone (20% boosts to Thief Class attributes), Shadow Stone (invisibility) and Serpent Stone (paralyze), for special boosts for a thief/assassin. Note that you can have only one Guardian Stone's blessing/power at any given time, and you can invoke the power only once per day, so it is like the grand powers in Oblivion. "All abilities granted by these stones cost no magicka to cast and can only be used once every 24 in-game hours." Perhaps someone can make a mod to If you are frequently running out of lockpicks, you can complete the Thieves' Guild quests to get the unbreakable Skeleton Key. Or get the nice Lockpicksmith mod: http://www.skyrimnexus.com/downloads/file.php?id=1107 If you are just fed up of the lock-picking mini-game, then use the LockPick Pro mod (like I do :-): http://www.skyrimnexus.com/downloads/file.php?id=219 CHEATS (warning: using console cheats may have adverse affects if you are using Steam):