Well First off you WILL have problems with the game if you run FOOK2 and FWE. Second, If you are using FOOK2 v1.1 (which you should) you can't run destruction, because it only supports v1.0. Until they update to accommodate v1.1, you can not use this. Now, If you want to run Fook2 and FWE, I would suggest moving FOOK2 plugins above FWE's. I would also suggest you look up and download BOSS for Fallout 3, http://www.fallout3nexus.com/downloads/file.php?id=10193, which automaticly sorts your load order in FOMM (which if you do not use fomm already, I highly suggest that you do.) Now, the red squares and exclamation marks means that the game could not find a mesh, which means you downloaded something wrong and put it somewhere other than where it's suppose to go. I have also had problems with the unoffical patch conflicting with fwe/fook2. Use Boss, follow it's suggestions and see where that gets you. Also, I see you are running plugins without its masters, make sure the esm's are ABOVE the esp's and that what is required for the esp's are also loaded before it. (FOOK destruction needs Destruction and all it's plugins to be running and above it in the load order to work properly).