I had this issue today, and resolved it pretty quickly. Keep in mind that mod conflicts can cause this issue, but that was not what caused it in my case. I had the loading issue, but could load if I tabbed out, and then back in. Near the Corvega Plant, and Boston, I would get crashes. For me, the issue was within my Fallout.ini and FalloutPrefs.ini files. My uGridsToLoad was set to 15, and my uExterior Cell Buffer was set to 290. First of all, that is a bit too high for my computer specs. Second, uExterior Cell Buffer must be set to the following value, or the game will have this loading bug, as well as crashes: if uGridsToLoad=13, then uExterior Cell Buffer=196=(13+1)² When you are finished fixing your .ini files, be sure to go to their properties tabs, and set them to read-only. That way, your edits will be maintained. EDIT: I fixed my .ini files, and that seemed to help, but something else that I did made the issue come back. This mod finally solved the issue for me. https://www.nexusmods.com/fallout4/mods/44798