Trying this again in the dedicated New Vegas technical support forum, since the last thread probably got deleted for not being in the right place(I didn't realize how deep the categories went). I have two systems running New Vegas/TTW on my laptop(Asus Strix w/GTX 1070 and an M.2 card) and my self-built tower(AMD FX-8350; MSI RX560 Aero; 32GB Corsair Vengeance 2400mhz DDR3; Samsung 850EVO 500Gb M.2; ASRock 990FX Killer mobo) with identical mod lists and loadorders(barring maybe standalone equipment mods). I can save/autosave as much as I want on the laptop with zero problems, but my tower only allows me to save once normally before locking up for 2-3 minutes at a time. A quick look at the Performance tab of Task Manager shows that, during any save past that first save, the active time on my C: drive(the 850EVO) jumps to 100% and my read and write speeds drop to 0kb/s for the entire duration of the saving process, after which the game saves normally. This is the first time I have experienced anything like this since New Vegas was released and I am completely and utterly confused as to what would cause this. On both systems, Nexus Mod Manager, Steam, New Vegas, and all of the mods are located on the C: drive/M.2 card.