Hard to decide, maybe Phantasy Star Online, but that's more for the people than the game. I love all the Final Fantasy games I've played (7 to 12, excluding 11), Borderlands, Morrowind/Oblivion/Skyrim and the Fable series
Woohoo! *high-5's to fellow shoe fetishist!* and you like Borderlands too ;) Kudos right back atcha! They started development on the 2nd game already, you should check it out... they have a dwarf duel-wielding guns XD