I am now facing the exact same problem. Had a bunch of mods installed, manually, game was running fine. Decided to switch to NMM because my list was getting quite long and manual management was getting troublesome, did a clean install of the game, and reinstalled all my mods (the same ones as before) with NMM. Now everytime I get to the stand by screen before the main menu it crashes. The moment I activate even a single plugin the game stops functioning. Steps taken to correct this problem: Clean game install: 3 times Verify integrity: 20+ times Clean NMM install: 5+ times (Clean install means also manually deleting the fallout 4 remaining files, fallout 4 my document files and fallout 4 appdata files, and playing the vanilla game for a bit to get the new files sorted and created) Installing mods 1 at a time, and booting the game after every install: 3 times Here's the funny thing, the crash starts happening with random mods, a mod that worked fine (was even playing with it and using it ingame), the first and second time, proved to be causing the crash on the third try. The above leads me to believe that either it is completely random, which is messed up for troubleshooting, or I'm missing some major elephant in the room. If anyone has any idea how to fix this, it would be most welcome, or i would be forced to switch back to my manual installation until this problem is proven to be solved. Side Info: - NMM, Steam and Fallout 4 all installed on the same drive - NMM run as Administrator - F4se installed, tried with both the 1.3 version for non-beta and 1.5 version for beta System Specs: Windows 10 Home, 64-bit Intel I-7 core, 2.4GHZ 8GB RAM Nvidia GTX850m Load order directly from NMM: GameMode=Fallout4 Fallout4.esm=1ArmorKeywords.esm=1Robot Home Defence.esm=1SpringCleaning.esm=1Food&WaterGenerator.esp=1DifficultyXPScaling.esp=1no_level_reqs.esp=1DarkerNights.esp=1TrueStormsFO4.esp=1SC_ExpandedScrapList.esp=1Armorsmith Extended.esp=1Crafting Workbench.esp=1Crafting Workbenches - Ammo.esp=1DV-Deadly Vertibirds.esp=1CompRedo.esp=1Companion Infinite Ammo and Unbreakable Power Armour.esp=1Craftable Armor Size.esp=1LegendaryModification.esp=1LongerPowerLines3x.esp=1MoreSpawns_High.esp=1NegativeAffinityIsPositiveAffinity.esp=1NoAffinityCooldown.esp=1Realistic Survival Damage.esp=1SniperDamage v3.0x.esp=1MinigunDamage v2.0x.esp=1LegendaryRarity10.esp=1LegendaryAllDifficulties10x.esp=1Combat_Helmet_Illumination 1.2.esp=1AnS Wearable Backpacks and Pouches.esp=1VatsOverThere_IncreasedVATSRange_AimIncreaseMaxed.esp=1Brotherhood of Steel Kit.esp=1GlovesOfTheCommonwealth.esp=1Simple Intersection.esp=1AnS Wearable Backpacks and Pouches - Ballistic Weave.esp=1AnS Wearable Backpacks and Pouches - No Crafting Perks.esp=1LegendaryModification2LM.esp=1LegendaryModification2LMAKPatch.esp=1LegendaryModificationCSA.esp=1LegendaryModificationGroknak.esp=1LegendaryModificationMisc.esp=1Crafting Workbenches - Ammo Expanded.esp=1Crafting Workbenches - Ammo Special.esp=1Crafting Workbenches - Junk Items.esp=1Crafting Workbenches - Power Armor.esp=1Crafting Workbenches - Pre War and Manufactured.esp=1All Military Skin pack.esp=1t45Metal.esp=1T45BattleDamaged.esp=1T45Military.esp=1TrueStormsFO4-LITE-Audio.esp=1TrueStormsFO4-ClimateSettings.esp=1Armorsmith Combat Helmet Illumination 1.2.esp=1AnS Wearable Backpacks and Pouches - AWKCR.esp=1Crafting Workbench - GlovesOfTheCommonwealth Patch.esp=1TrueStormsFO4-NoConstantRads.esp=1DarkerNights-TrueStorms-LITE-Audio.esp=1DV-No Levelled Vertibirds.esp=1DV-Vertibird Explosive Minigun.esp=1