I found a work around, it doesn't resolve it, but it will let you start the game with the mod. Launch the game from NMM, wait until the PLAY screen for Fallout 3 appears, then select the desired plugin(s) in NMM. I have 4 turned on before starting FO4 from NMM, and watch them turn off as soon as the game screen appears. I select them again and then hit play on the game screen all all the mods stat with the game. need this resolved though, I don't want to have to select my mods every time I play.