Hrm, I'm having the same issue where I can't even start a new vanilla game without it crashing. And it's INSTANT... as soon as I try to load a game, CTD... only once did it ever pop up and say that some data is no longer associated do I wish to keep loading, and it CTD before I could even answer anything, like as soon as it came up. When starting a new game, takes about 3-5 seconds to CTD. However, I'm not, nor have I ever installed Gore Overhaul (will double-check just to be certain). I noticed one person said making plugins.txt read-only fixed it (which I thought NMM already did? Or was that another file?). Also see people mentioning to roll back before the beta patch. So guess those are my steps... 1. Check to see if I've ever used Gore Overhaul. 2. Check to make sure plugins.txt is read-only. 3. Roll back patch. Thanks Bethesda... could you please stop taking business-practices from Microsoft/Windows in the future!? FFS! >_< EDIT: Confirmed; Gore Overhaul doesn't look familiar. Though, does have me thinking/wondering if there's a chance that there's other texture-replacements that could be causing the issue. If so, gonna' be a bumpy ride as I've installed tons of texture-replacements... form Pipboy-map, to trees, to stars, to sky, to armor, to clothing, to some weapons, to world textures, even to junk items like Mac'n'Cheese, Abraxo, etc. -_- EDIT2: Seems my plugins.txt AND loadorder.txt (loadorder wasn't originally, but still no luck after read-only and restart of NMM) in Users/<username>/AppData/Local/Fallout4 is already set as read-only. So guess my final solution is to rollback the beta patch... lovely. >:-/