Hello, I'm attempting pretty much the same right know. Here's my experience concering some of the questions in this thread based on my 10 hour test character. Please note the playtime, so there could be issues that I overlooked or simply did not experience yet. Also, all mods are bashed if not stated otherwise. Vilja is fully compatible since the mass effect requiem update, I noticed no issues. Since this is stated in the file description, I have no reason to assume otherwise. Requiem: Hard Times by Azirok makes Requiem compatible with the unofficial patches. If you don't want Hard Times, there's an optional file just for the compatibility. Also Azirok has made a ton of patches for some popular mods to use with requiem. I choose the ones for Immersive Creatures, Immersive Patrols and Dragon Combat Overhaul, with no issues so far. OBIS also has a patch(beta) for Requiem by ArtMurder which I'm currently running. Since this is my first time playing OBIS I can't really say if it's working correctly. I did however encounter my fair share of OBIS Bandits so far. According to the author OBIS needs to be installed with the Dragonborn options and you may need the Requiem: Dragonborn patch by Azirok. Interesting NPCs doesn't have such a patch, so I'm guessing the bashed patch is absolutly mandatory. I've encountered about a dozen new NPCs, all of which seemed to function as intended. I'm also running Deadly Dragons which has no direct patch for requiem. You can however make it compatible with the Dragon Combat Overhaul, which in turn can be made compatible with Requiem. It's a bit of a long shot but seems to work for me, at least right now. I'd advise against DD Deadly Monsters and the DD loot mod though. Also bashing helps. Since a lot of mods that came up here add NPCs, a bit of advice: don't overdo it. If a trade caravan form INPCs runs into fight between a bandit and a guard patrol next to a civil war battle from CWO, thats pretty much a guaranteed crash, especially if you upped uGridstoload. So if you're having trouble with CTDs, thats a good place to start looking.