Hello EVERYONE I am excited and pleased to provide a SOLUTION to this problem. (SKSE will not start with ENBoost installed SOLVED) Firstly there is an EXCELLENT guide on Reddit here For THIS particular problem of the ENBoost NOT starting with SKSE, Skyrim Launcher or TESV.exe you need to pay attention to this line on the ENB dev webiste -"d3dx9_26.dll, d3dx9_40.dll, d3dx9_43.dll - required to run ENBSeries, if game won't start with modification and display error message, download DirectX Runtime from microsoft.com web site, they are not exist in system only for those users, who did not update DirectX several years or did clear installation of OS recently. If you need them, unpack to same folder, where ENBSeries is. Also you can put these files in to system folder of your windows installation." This indeed in needed to have ENBoost work. So thus I DL'd the DX Runtime SDK and installed. Once that was done I was able to start the game AND the game message at the top left corner verified that ENBoost was infact running (I did set every launcher and ENB to run as administrator) I am sure I'm a bit late to this party and perhaps this is old news but I could not find a succinct solution through Google. This WORKS with BOTH the Wrapper and Injection version I downloaded v. 0.265 Hope this helps EVERYONE Happy Gaming!!!