Yes, just started having the same problem. I'm running the Steam version FNV on an AMD machine with XP Pro and minimum mods. Won't list them here because up until yesterday, FNV was working fine (the last mod was installed weeks ago). Then, in the middle of the game, it crashed and I got Window's "Blue Screen of Death" and my computer rebooted. Since then, FNV all the way through the introduction screen, but when I select "Continue" I get the usual starting screens (with tips about the game), then I'm dropped back to the desktop. Obviously one of the files got corrupted. I'm very far into the game and don't want to lose anything. I've saved my Saved files and my Data files. But I'm still concerned that I will have to go back to the beginning if I do a reinstall. Any suggestions will be greatly appreciated.