In response to post #37012155. #37013770 is also a reply to the same post. I'm running the beta and using mods as well, flawlessly. My ini changes related to mod activation: Fallout4.ini: [Archive] sResourceDataDirsFinal= bInvalidateOlderFiles=1 Fallout4Custom.ini: [Archive] sResourceDataDirsFinal= bInvalidateOlderFiles=1 Fallout4Prefs.ini [Launcher] bEnableFileSelection=1 I have to say that I had to reinstall the game because I was having crashes on start too, but considering the stuff I tried before that ultimate reinstalling solution, maybe you could try deleting your ini files and launching the game (forcing the game to restore the original ini files), and then adding these lines to the inis. Maybe, just maybe, it solves the problem and you can skip the reinstallation thing. Of course don't forget to put the "*" symbol before your mods in "plugins.txt" required for the mods to work in beta. Also backup the files (inis and savefiles) before touching anything if you don't like surprises. I hope this helps somehow =/