I've noticed there's at least a couple of abilities and some cyberware that requires a takedown to activate it's effect.
The inteligence tree for example has a perk that reduces trace progress after a takedown, I personally never bothered but I think one could breathe more life into these abilities by letting them trigger on an undetected kill with a ranged wrapon, like throwing knifes and silenced pistols.
This would synergize very well with the cyberware piece that increases your headshot damage on takedown, when I first tried it out, this is what I was hoping for, a self contained loop of increasing headshot damage.
Tldr. If undetected kills from ranged weapons were to count as takedowns, it would unlock a lot of synergies