Me again. Did some more playing around and went ahead removed nmm and then reinstalled it. However, this time I went ahead and installed under program files. I then made sure that my login id had read/write access to C:\Games\Nexus Mod Manager. I realize that my id was already a member of the administrators group but I decided to go ahead and added it anyway. Now NMM is working under windows 10. I did have to update the fallout4prefs.ini again. The only issue I have now is that NMM keeps unchecking all the mods under plugins for some strange reason. I have to make sure they are all checked. They seem to come unchecked after I exit the game. Still trying to figure that one out. Anyway everything is working except for the mods that need to be update to the last game version 1.2. At least I can map the numeric pad again. They just released a patch for NMM.. hope that helps!