I'm having the same issue with the bloated file. I have been experiencing periodic lags for a while now but in the last 24 hours things changed a little. This time it started with being randomly teleported to the Mzinchaleft Great Lift in middle of gameplay every so minutes. I found out this is a bug when using the lift, so I finally solved it by making a mod which disables the lift entirely. Then I got this problem where the beast form skill is buggy and won't change the race of my character to the werewolf, so basically my character stays the same but I cannot open the favorite menu, skill menu, map etc. I need to use control commands to go around this and haven't managed to fix it. I tried leaving the game running for the night (approx 8 hrs) in the hope that the character would shift back on its own (and to check if the Mzinchaleft bug returned, but it didn't), but at my wake I just found him naked in the middle of nowhere. The skill is still broken. However to my surprise the savefile has gone from 17MB to 45MB and lags are now more frequent and take longer. I have found this apparent solution and haven't tried it out yet, www.gamefaqs.com/boards/615805-/63546645 otherwise I wouldn't know what else to do.