Hey there, thanks for your answer! First of all, yes, you are correct, MasterUpdate does not check for conflicts; however I use it to check if my load order is screwed up or not , and that's what I meant by "no conflicts" in the original post. And yes indeed, FO3Edit does show a lot of conflicts, yet they don't look like they should be crashing anything. I tried a few solutions yesterday, and here's what seemed to have caused the problem (can't be sure since I haven't tested extensively yet): I believe MTC Wasteland Travellers was the issue. It was rather weird actually, because after I unchecked it in Mod Manager (unchecked, not deleted), the game started to crash on 'Continue' (I don't use autosaves and run CASM instead), yet it stopped the sporadic crashing. And crashes on 'Continue' got fixed by deleting the mod completely, including the backups, and saving in an interior. Again, I didn't manage to test extensively so far but I hope the issue got resolved; after I make sure that there are no CTDs any more, I'll try installing UCO back, which will probably break everything again but at least I'll know what the problem is. Thank you for your help!