Hi, I've recently solved similar issue and wanted to share it with you guys, it might work for you aswell. After countless enable/disable mods accordingly to FO4Edit I managed to find ones that CTD my Fallout. -Weapons Mods Mod (quite a few weapons, mostly 10mm, mod tries to snatch it to n99) -Bison Shotgun (combat shotgun) -Better Handmade Weapon Textures (pipe pistol/etc stuff) - also Optional Rustic addon After complete uninstall everything works fine, no crashes, even with my 300+ mods installed, still needs some testing tough. It was a real pain to play on survival, when you can't save the game and crash in most unexpected ways losing all your progress.