What if I just wanted to replace some of the audio files with recordings of my own? I remember trying to do that with Morrowind and it plain didn't work. Didn't make it crash, though; instead, no audio file was registered when it came time for certain characters to use the audio file that would've been there. So, again- just replacing audio files with my own...what would that take? I know of plenty of mods (Wilhelm Scream, Swearing Mudcrabs/Trolls, Auto-tuned Bears) where modders have recorded their own voices (or taken soundbytes) and replaced the reaction noise with those files, so I can't imagine this should merely be passed off as "CK-only", like the OP's original query.