I had terrible lag in Whiterun too. During day time, down to 2 frames per minute at times! after trying lots of graphics card tweaks and many other things, I finally solved it, not perfect in worst parts of whiterun but more than playable. I disabled HighRes Texture pack 01, 02 and 03 in mod manager (something I had done before to no success) I deleted my skyrimprefs and skyrim.ini (Documents/My Games/skyrim) Reinstalled my Cleaned (by TES5Edit) mods for Update.esm/Dawnguard.esm/Hearthfire.esm) original vanilla.esms still in data folder! Launched skyrim from steam to reapply ini files and reset graphics. Ran LOOT to set mod order again. Launched skyrim again with SKSE shortcut. Unplayable stuttering finally gone, for good I hope, Those HighRes texture packs are very old:P Only just tested it but took a day of pain, and seams ok at mo, thought I had broken my game! Thanks to all the great modders who really understand all this stuff!