For a while now I've been unable to load any save game (well, almost any). I start a new game, play around a bit, save and exit. Then next time I want to play I try to load the save, and it looks like it's gonna load just fine, takes about the same amount of time it used to if not a little bit longer, then BOOM, CTD with no warning or anything. I can start a new game no problem, and the save files are around 5mb, so it's not because they're too big. For at least a year now I've been using ENB, just for the parallax and enboost, and I've got the latest version of SKSE. I'm also using Mod Organizer. I've got an nvidia gtx660, i7-2600 3.4ghz (OC 3.8ghz), and 8 gigs of ram, so I don't think it's too much for my computer to handle, especially since I've been able to play when I only had 4 gigs or ram and a gt520.