I am having the same issue CTD right after bethesda logo/skyrim log right before main menu. I got it to work on my older computer with very minimal settings. Toshiba satellite 2008 model (Laptop) AMD RADON 2100 single core sempron etc. My new computer Is a Dell Insperon Special Edition 17R I7, 1TB HDD, 8GBRAM, 2gb Dedicated Graphics nvidida geforce gt 650M. I should be able to run this game just fine. However, i have no mods or DLC installed and it still crashes...and if it helps im not running it through steam...Like i said i got it to work well enough to play on my older computer but on my new one i have no idea. I also do not have any updates or patches.