Same thing here. I had all my mods working (well over a hundered of them) and then I was stupid and thought I would update my catalyst drivers. After that nothing but woe. I uninstalled the Application Profiles and deleted my old skyrim folder in My Games and launched from Steam with no luck. I then tried to launch from NMM and same thing. I've tried deactivating certain recent mods and it just hangs up before you get to the "Bethesda Presents" opening when starting a new game. If I find the mod doing this I'll post it. It happened a few days before and I saw the post about the CK mods and deactivated it and that fixed the issue. But now I don't know what it is.
