I have set up Vortex and within the 'Settings' > 'Downloads' menu, I have enabled the 'Handle Mod Manager Download buttons on NexusMods'. I have also closed Chrome and clicked the 'Fix Now' button next to 'Fix Nexus Mods links in Chrome'.
From this menu, if I click on the link to 'NexusMods.com' I get the hourglass for half a second and then no other result. Chrome does not open the link, and no error is reported.
From the 'Mods' menu, in the 'Actions' column, if I choose 'Open on Nexus Mods' for any of my installed mods, I get the same result. Approximately half a second of hourglass, and then no other result. I can also use the 'Check for Mod Updates' option and the list does display mods that need to be updated along with their version info, but if I click the Cloud icon to initiate an update, I get the same results.
Within Chrome, I am running an AdBlocker that is disabled on NexusMods, so this may be causing a conflict, but I do not know that for certain.