I have 253 mods currently active. This isn't counting the Skyrim.esm or the official patch. If I add 1 more, it starts acting very wonky. It doesn't matter what mod I add, it screws up the same way each time. Without that extra one loaded, it works perfectly fine. Initially, it would crash at the title screen. Now, it actually loads the game, but I am suddenly in the Bannered Mare, and I die immediately on load in. If I activate God Mode quick enough, I live, but the screen starts flashing black every half second or so, and I start getting 5 food items added constantly to my inventory. All my quests get restarted as well. So, I get all the quest popups. This only happens if I add the total to 254 plus Skyrim.esm and patch. So, as stated before, the limit is 255, but that counts Skyrim.esm and the patch as part of that total unlike nosisab stated.