I am, sadly, having this problem as well. I updated from Windows 7 to 10 late last year, so I assume that's the main reason things are screwy. However, none of the posted fixes have worked for me, and stranger still is that I wasn't having this problem at all at first. --- To make a long story short, I opened up Vortex for the first time in a long, long while, loaded my Skyrim profile, and started downloading a few new mods. I was able to install them just fine, and could even access the sub-windows that let you pick your mod options and all that. Then, suddenly, while I was trying to install a texture mod (entirely cosmetic, nothing fancy), trying to install it suddenly prompted me to download .NET. I did just that, downloading the program and clicking on Repair, but even after a second attempt-and-repair, the problem kept happening. I downloaded the newest up-to-date version, installed it, and the problem still kept happening. So on and so forth. If it's of any referential help, Steam itself is installed on my C: drive, Skyrim and my other Steam-based games are on my D: drive, and I set Vortex up to direct my mods to a separate folder on the D: drive as well. I'm tempted to just disable sandbox as a short-term fix, since I don't really use Vortex for any other games, but it's still kind of a bandaid solution, y'know?