I do use SKSE, I run Win10 pro, and i clean as stated in the cleaning guide linked on the TES5Edit page. By Game crashes midway through gameplay i mean that, while playing the game with fairly normal framerate and performance i get a crash to desktop out of the blue. I think the crashes might be related to VRAM though, as i only have 2gb, and sometimes the textures would be replaced with pure black textures which from what ive found is related to VRAM. I ran Skyrim performance tracker and my VRAM maxed out and plateaued at 2gb until the crash.