Particularly noticeable with this save - when it loads, you've handling an invisible gun. I get the "some DLC is missing" error when loading up saves, but haven't played enough of the game to find out whether it is actually missing (all the .bsa files are being loaded through the launcher). Also, this happens with New Vegas, and unfortunately with NV, any save I open gives me all the DLC extras, making me overencumbered. Both games patched to the very latest versions.